Sr. Manager, Data Scientist

Sr. Manager, Data Scientist
United States - California - Oceanside

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company's five core values. That's because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

Gilead Sciences is continuing to hire for all open roles. Our interview process may be conducted virtually and some roles will be asked to temporarily work from home. Over the coming weeks and months, we will be implementing a phased approach to bringing employees back to site to ensure the health and safety of our teams.

For Current Gilead Employees and Contractors:
Please log onto your Internal Career Site to apply for this job.

Job Description

Gilead Sciences, Inc. is a research-based biopharmaceutical company founded in 1987, is seeking a highly motivated Research Scientist to join our Analytical Operations team in Oceanside, CA. The Research Scientist will be responsible for collaborating with colleagues in planning and executing experiments and analyzing data to generate knowledge. You will join a team of scientists who are supporting advanced approaches to the Analytical development of new drugs and improvements to existing commercial products. Examples of positive benefit we have seen are in statistical analysis of complex kinetic data, application of artificial intelligence to stability data and the integration of statistical principals during analytical method development.

Job Responsibilities:

• Participate in a team in the development and maintenance of business applications.
• Participate in the evaluation, design, and development of applications that automate and support across Development.
• Provide systems administration and technical support for non-GMP and GMP regulated environment.
• Co-ordinate with Infrastructure, IT and Database administrators to ensure continuous system availability.
• Provide architectural solutions for interface developments.
• Support the development of use cases and documentation of user requirements and functional requirements specifications to ensure that requirements are complete, accurate, and testable.
• Support the development of test strategies and defining test data (design the approach for testing each requirement).
• Document and manage software defects, issues and enhancement by providing assessments and work with business and Information Technology partners to enhance applications to reduce operating time and improve efficiency.
• Investigate project feasibility, prepare project cost and benefit and estimate project resource needs for staff and consultants
• Provide end-user support for various platforms and systems.
• Participate in training, design, documentation and delivery efforts with the project/delivery lead.
• Provide systems training to end users, contributes to process improvements and the evaluation of third-party products.
• Consult with users, management, and vendors to assess computing needs and system requirements.
• Represent the organization in providing solutions to difficult technical issues associated with specific projects.
• Contribute to the completion of specific programs, projects or responsible for individual business targets.
• Apply concepts of risk assessment, Design of Experiment, Quality by Design, Analytical Target Profile (ATP), simulations (e.g., Monte Carlo) to predict and understand behavior/outcomes during the development of robust analytical methods and processes for small and large molecule drug substances and products.
• Apply statistics in the evaluation of data and design of experiments to support the process & analytical method lifecycle from early development through to continued process verification (CPV) and continued procedure performance verification (CPPV).
• Model accelerated predictive stability data to inform product expiry, storage, and packaging.
• Perform trend analyses and use control charts to make suggestions to specifications.
• Apply simulation to support quantitative risk assessment.
• Understand and apply multivariate methodologies, such as principal component analysis (PCA) and partial least-squares (PLS), in the development of analytical methods.
• Understand and apply data science (regression, classification, natural language processing etc.) to gain insights and provide solutions to business problems
• Use industry leading statistical and chromatographic modeling software such as Fusion by S-Matrix, DryLab, JMP (SAS or equivalent), R, Python, ASAPprime, MatLab for advanced data analysis (e.g., with PLS Toolbox by Eigenvector).
• Generate scripts and/or applications for automating data cleaning, preprocessing, exploratory analysis, predictive analysis, and final reports
• Work with more senior scientists or scientific directors to advance state-of-the-art techniques and approaches to in the development of drug substances and products.
• Direct and advise junior staff and colleagues in the execution of experiments and data analysis.
• Present results of work, interpret data, and draw data-driven conclusions.
• Maintain full working knowledge of principles and theories, applying such knowledge to the direction that supports company interests.
• Think critically and creatively and be able to work both independently and as a part of the team, determine appropriate resources for resolution of problems and have strong organizational and planning skills.
• Potentially contribute to scientific literature and conferences or regulatory filings.

Education, Experience and Skills:

• PhD in chemistry, chemical engineering, pharmaceutical sciences, biology or other scientific field with 2+ years or MS with a strong mathematics component and 8+ years or BS with 10+ years of working experience
• Experience with design of experiment (DOE), Quality by Design (QbD), and Statistical Process Control (SPC)
• Strong background in statistical and modeling techniques (i.e. linear and logistic regression, multivariate linear models, Bayesian inference techniques), and computation methods (linear algebra, integration, interpolation, ODE solvers)
• Proficiency with one or more statistical/programing languages such as Python, MatLab, R, JMP (SAS or equivalent)
• Familiarity with visualization tools such Tableau, Spotfire or JMP
• Ability to lead & manage multi-disciplinary data science projects
• Familiarity with pharmaceutical development and common analytical techniques (e.g., HPLC/UPLC, GC, and Mass Spec)
• Proficient in Machine Learning and Artificial Intelligence concepts
• Excellent communication skills (both verbal and technical) and interpersonal skills are required. Must be able to work in highly flexible and cross-functional teams

For jobs in the United States:
As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S., Canada, Australia, and Singapore employees and contractors to receive the COVID-19 vaccines as a condition of employment. "Full vaccination" is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.

For more information about equal employment opportunity protections, please view the 'EEO is the Law' poster.

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:
Please log onto your Internal Career Site to apply for this job.

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